|Physical Appearance||White freeze-dried powder|
|Test Method||1,Analysis by SDS-PAGE. 2,Analysis by HPSEC|
|Biological Activity||≥12000 ATU / mg,95%|
|Application||1, Cosmetics additive; 2, Pharmaceutical additive|
|Superiority||1,In the the same measurement unit, the specific activity of recombinant hirudin is much higher than Natural hirudin, so Re-hirudin has high-usage. 2,high purity and low sensitive rate.|
|Storage||4ºC, store>1 year; -20ºC, store 1-3 years; -70ºC, 3-5 years.|
Recombinant Hirudin technique data
|Recombinant Hirudin is a potent thrombin inhibitor originally derived from the medicinal leech unlike heparin. Hirudin acts directly on thrombin rather than through other clotting factors. The mechanism of Hirudin-thrombin appears to be unique. The conversion of fibrinogen into fibrin by the serine protease enzyme thrombin is a major event in the final stages of blood coagulation. In the final stages of coagulation prothrombinase converts prothrombin into thrombin. Fibrin is subsequently cross linked by factor XIII to form a blood clot. The primary inhibitor of thrombin in normal blood circulation is antithrombin III. The anticoagulatant activity of hirudin is derived from its ability to inhibit the pro-coagulant activity of thrombin (similar to antithrombin III activity). Hirudin is the strongest natural inhibitor of thrombin. Hirudin binds to and inhibits only the activity of thrombin forms with a specific activity on fibrinogen contrasting to antithrombin III activity. Therefore, hirudin has a thrombolytic activity since it prevents or dissolves the formation of clots and thrombi. Hirudin also has therapeutic significance in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins. Hirudin does not hinder with the biological activity of other serum proteins and can also act on complexed thrombin, thus having an advantage over more common anticoagulants and thrombolytics like heparin for example. It is complicated to extract large quantities of hirudin from natural sources; therefore a method for producing and purifying hirudin using recombinant biotechnology has been developed.|
Paper of Dr. Ren from University of Toledo, he used our recombinant hirudin for his test.
Dalian Free Trade Zone United BoTai Bio-Tech Co.,Ltd., was incorporated in 2006. It is a high-tech biological company specifically committed to research and developing proteins, manufacturing and marketing biological products.
We are now cooperating with National Laboratory of Protein Engineering of College of Life Science Peking University and other well-known institutions, have successfully developed and optimized Metallothionein(MT), Gene recombinant Hirudin(HV2), Interferon(α-2b), Interleukin-2(IL-2), Epidermal Growth Factor(EGF), human Intestinal Trefoil Factor(ITF), and other nearly 30 kinds of proteins and biochemical reagents. They are playing outstanding roles in food, nutrition & health care products, beauty & skin care products and analysis of pharmaceutical research.
In cosmetics field, our protein cosmetic products have lots of functions. It can delay senescence, anti-acne, remove heavy metal toxins, protect skin from the sunlight ultraviolet, whiten skin, lighten dark spots, remove scars, moisturize skin etc. There is no any harmful ingredient in the products. The proteins we are using can improve the blood microcirculation from inside, solve your skin problems fundamentally, let your skin glossy and healthy. The protein skin care products are not only popular in domestic market, but also in overseas market. The products have been sold all over the world. Europe ,North America, Australia, Asia all have our protein skin care products. We have cooperated with a US cosmetics company for many years, and our ODM cosmetics products have been large exported to USA. The products experienced multiple inspections from the FDA and from US Border Patrol/Customs and we passed smoothly! Now, our ODM products have entered the Lord&Taylor shopping mall in the fifth avenue in New York and sold by many famous cosmetics companies of USA .
In biological and other field( Pharmacy and health care),our products also have special features. Many universities use our proteins for their experiments, such as University of Toledo, Indian Chandigarh University, Tsinghua University, Zhejiang University, Jinan University, Military-Medical Academy, the Third Military Medical University, the Forth Military Medical University, Hong Kong University of Science and Technology, Fudan University, Beijing University of Chinese Medicine, Nankai University, Chinese Academy of Sciences Institute of physicochemical, China Medical University, Liaoning Drug Research Institute, Wuhan University of Technology, Dalian University of Technology, Jilin Medical Collage, Southern Medical University , Zhejiang Foresty&Farming University, etc, and get good results. The health care products can remove garbage in the blood, it is good for the treatment of kidney diseases and cardiovascular diseases, without any negative consequence. The bio-protein and health care products not only gain good feedback in domestic, but also sold in global market. USA, Canada, Germany, Italy, Russia, Australia, Malaysia, Indonesia, Thailand, India, Pakistan, Dubai(UAE),Hong Kong, Taiwan and so on, our products spread all over these countries and areas.